Developing Robust & Translatable In Vivo Models for Retinal Vascular Disorders to Better Replicate the Human Retinal Vascular Environment
Time: 8:50 am
day: Pre-Conference Workshop
Details:
Finding the appropriate in vivo models can be a challenge for any disease indication, but developing these models for retinal vascular disorders poses a completely new set of hurdles. Due to the lack of animal models with similar physiology as the human retinal vascular system, it can be complicated to test safety and efficacy in preclinical settings before moving on to clinical trials. Moving forward, it is vital for the field to have accurate in vivo models to replicate the blood-retinal barrier consisting of microvascular endothelial cells, pericytes and barrier permeability for better translatability of drugs for retinal vascular diseases.
Here’s what you can learn by joining this workshop:
- Bridging the gap in knowledge between retinal and macular vasculature in animal models such as rats, mice, rabbits and monkeys, and human retinal vascular system • Discussing the required criteria for in vivo models to leverage safety data for successful translation into phase I clinical trials for Wet AMD
- Advantages and disadvantages of using models with laser-induced geographic atrophy which results in choroidal neovascularization
- Tackling the challenges of developing in vivo models for DR and DME to replicate the polygenic environment
- Developing in vivo models mimicking interactions between retinal microvascular endothelial cells and pericytes for accurate representation of wet AMD
- Finding appropriate animal models of Wet AMD vs DME vs DR to test target pathways for each disease pathology
